NO. (1)
Title: Design of an optically stable pH sensor based on immobilization of Giemsa on triacetylcellulose membrane

Authors: Khodadoust, S (Khodadoust, Saeid); Kouri, NC (Kouri, Narges Cham); Talebiyanpoor, MS (Talebiyanpoor, Mohammad Sharif); Deris, J (Deris, Jamile); Pebdani, AA (Pebdani, Arezou Amiri)

In this work a simple, inexpensive, and sensitive optical sensor based on triacetylcellulose membrane as solid support was developed by using immobilization of Giemsa indicator for pH measurement. In this method, the influence variables on the membrane performance including pH concentration of indicator, response time, ionic strength, and reversibility were investigated. At optimum values of all variables the response of optical pH sensor is linear in the pH range of 3.0-12.0. This optical sensor was produced through simultaneous binding of the Giemsa on the activated triacetylcellulose membrane which responded to the pH changes in a broader linear range within less than 2.0 min and suitable reproducibility (RSD < 5%). Stability results showed that this sensor was stable after 6 months of storage in the water/ethanol (50:50, v/v) solution without any measurable divergence in response properties (less than 5% RSD).

NO. (2)
Title: A sensitive electrochemical sensor for rapid and selective determination of nitrite ion in water samples using modified carbon paste electrode with a newly synthesized cobalt(II)-Schiff base complex and magnetite nanospheres

Authors: Parsaei, M (Parsaei, Mozhgan); Asadi, Z (Asadi, Zahra); Khodadoust, S (Khodadoust, Saeid)

In this work, a simple and sensitive electrochemical sensor was developed for determination nitrite ion in water samples by using carbon paste electrode (CPE), which is modified with magnetite nanospheres as nanostructured materials and a newly synthesized cobalt(II)-Schiff base complex. The effects of various experimental parameters on the electrochemical oxidation response of the nitrite ions were investigated and optimized. At the optimum conditions the sensor has a linear response in the 0.2-30.0 mu mol L-1 concentration range and a low detection limit of 1.5 x 10(-2) mu mol L-1 of nitrite. The results showed that the modified electrode has higher sensitivity toward nitrite ion in comparison with unmodified carbon paste electrode (CPE) and/or its nanomaterial-modified form. Obtained results showed that the modified electrode could be successfully applied for determination of nitrite in some water real samples.

NO. (3)
Title: An Experimental Study of Different Drying Methods on the Quality and Quantity Essential Oil of Myrtus communis L. leaves

Authors: Rahimi, MR (Rahimi, Mahmood Reza); Zamani, R (Zamani, Roghaye) ; Sadeghi, H (Sadeghi, Hossein); Tayebi, AR (Tayebi, Ali Rahmani)

Myrtus communis L.is one of the most important aromatic and medicinal plants that used in the food, pharmaceutical and cosmetic industries. The effect of six drying methods (shade, Oven 40oC Oven 60oC, Microwave 700W, Vibro-spouted bed (VSB) 40oC) on yield and chemical composition of essential oil of M. communis leaves was investigated. The oils from fresh and dried leaves were isolated using hydrodistillation in a Clevenger apparatus and analyzed by gas chromatography-mass spectrometry (GC-MS).The highest essential oil yields were obtained by shade (1.87 %) followed by VSB 40oC (1.63 %), oven 40oC (1.35 %),VSB 60oC (1.23 %), microwave (1.05 %), oven 60oC (0.81 %) and fresh (0.47 %). Increasing the drying temperature significantly reduced the essential oil content of in VSB and oven methods. Forty-one components were identified in the oils of M. communis. The major constituents of the essential oil, -pinene (7.04-31.29 %), dl-limonen (14.98-21.58 %), and linalool (1.72-15.47 %), showed considerable variation regarding drying techniques. Tricyclene, as a new component, was only identified in VSB procedure (7.02 % and 8.07 %). -fenchylalcohol also found in VSB 60oC. Furthermore, in the microwave technique 3-cyclohexene-1-methanol (17.31 %) was found, while this component was not present in the other treatments. Therefore, these results showed yield and chemical composition of the essential oil from M. communis varied according to drying methods. Shade and VSB techniques could be considered as the two best drying techniques in term of essential oil yield and bioactive compounds contents. Moreover, VSB drying is desirable because of time saving.

NO. (4)
Title: Application of ultrasonic radiation for simultaneous removal of auramine O and safranine O by copper sulfide nanoparticles: Experimental design

Authors: Ghaedi, M (Ghaedi, Mehrorang); Khodadoust, S (Khodadoust, Saeid); Sadeghi, H (Sadeghi, Hossein); Khodadoust, MA (Khodadoust, Mohammad Ali); Armand, R (Armand, Raham); Fatehi, A (Fatehi, Allandad)


In this study, copper sulfide nanoparticles loaded on activated carbon (CuS-NP-AC) were synthesized by novel, low cost and green approach and characterized using SEM and XRD. The application of this material for the simulations removal of auramine O (AO) and safranine O (SO) from aqueous solutions was investigated. The dependency of removal percentages to variables such as pH, initial dyes concentration, adsorbent dosage, sonication time and sonication temperature were studied with response surface methodology (RSM) by considering the desirability function (DE). The quadratic model between the dependent and the independent variables was built. The proposed method showed good agreement between the experimental data and predictive value, and it has been successfully employed to removal of AO and SO in aqueous media. The studied adsorbent (0.06 g of CuS-NP-AC) was capable of high percentage removal (99.8% and 99.5%) of 18 mg mL(-1) AO and SO in short time (7.0 mm).

NO. (5)
Title: QSAR and docking analysis of A(2B) adenosine receptor antagonists based on non-xanthine scaffold

Authors: Mansourian, M (Mansourian, Mahboubeh); Fassihi, A (Fassihi, Afshin); Saghaie, L (Saghaie, Lotfollah); Madadkar-Sobhani, A (Madadkar-Sobhani, Armin); Mahnam, K (Mahnam, Karim); Abbasi, M (Abbasi, Maryam)

Partial least squares (PLS) method as ligand-based method was applied for building quantitative structure-activity relationships (QSAR) regression model to predict the inhibitory activity of some A(2B) antagonists. The accuracy and predictability of the developed model were evaluated by several validation methods using external and internal test sets and also the criteria recommended by Tropsha and Roy were met. The result of the PLS model had a high statistical quality (R (2) = 0.936 and Q (2) = 0.867) for predicting the activity of the compounds. Evaluation of a test set of seven compounds with the developed PLS model revealed that this model is reliable and has a good predictability. Because of high correlation between the predicted and experimental values of activity, PLS model proved to be a highly predictive QSAR approach. Also, the reliability of the model was assessed through docking for the selected antagonists as structure-based method. A potential binding site of A(2B)AR was verified according to the previous studies of site-directed mutagenesis. Phe173, Glu174, His251, Asn254, Lys269, Ile276, and His 280 were determined to be involved in ligand-receptor interactions.

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